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PD128907 HCl 是一种有效的选择性多巴胺 D3 受体激动剂,EC50 为 0.64 nM,选择性是多巴胺 D2 受体的 53 倍。
PD128907 HCl 是一种有效的选择性多巴胺 D3 受体激动剂,EC50 为 0.64 nM,选择性是多巴胺 D2 受体的 53 倍。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 316 | 现货 | |
5 mg | ¥ 748 | 5日内发货 | |
10 mg | ¥ 1,150 | 5日内发货 | |
25 mg | ¥ 1,930 | 5日内发货 | |
50 mg | ¥ 2,890 | 5日内发货 |
产品描述 | PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. |
靶点活性 | D3 receptor:0.64 nM (Ki) |
体外活性 | PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. [1] When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM) [2] PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.[3] |
体内活性 | PD128907 HCl is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. [4] PD128907 HCl (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. [5] The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling. [6] |
分子量 | 285.77 |
分子式 | C14H20ClNO3 |
CAS No. | 112960-16-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | Ethanol: <1 mg/mL H2O: 46 mg/mL (161 mM) DMSO: 10 mg/mL (35 mM) | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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